However, like all SSRIs, sertraline side effects do exist, and you should be aware of them before you consider treatment. In some cases, it is prescribed (but not FDA-approved) to treat acute bipolar disorder. Sertraline (often prescribed under the brand name Zoloft) is approved by the Food and Drug Administration for the treatment of many different mental health disorders, such as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder or panic attacks, major depressive disorder (MDD), social anxiety disorder (SAD) or premenstrual dysphoric disorder (PMDD). Safe and effective, sertraline has been used since the 1990s by tens of millions of people every year without major side effects. Once you explain your concerns to your doctor, the two of you can discuss all the options and determine which one might be the best for you.With tens of millions of prescriptions in the United States alone, sertraline is an FDA-approved and widely used SSRI medication on the market. Never go off an antidepressant on your own without your doctor’s OK, because stopping too quickly can lead to a resurgence of symptoms and other side effects. Whether you’re currently dealing with antidepressant-induced sleep fallout, or you want help for your depression but would rather avoid sleep issues if possible, the first step is to talk to your doctor, Breus says. For example, a doctor may advise a patient to take a sedating antidepressant at nighttime. Vivid dreams may persist for some people, but lots of times, these sleep issues will subside after a couple of weeks, he adds. “Most people will tell you they mainly see when they first start, then it goes away,” Winter says. These sleep-related side effects often aren’t permanent. If you’re freaked out by how your antidepressant has affected your sleep (or how one might in the future), there’s some good news. Other types of antidepressants can bring about either fatigue or insomnia as side effects. That can result in feeling extra-energized, potentially causing insomnia, Breus says. On the other side of the spectrum, norepinephrine and dopamine reuptake inhibitors, like the popular drug bupropion (Wellbutrin), increase the levels of those two neurotransmitters in the brain. “When somebody is taking an SSRI, they have more serotonin in their system for longer, which can have a sedating effect,” leading to sleepiness. “Serotonin is a calming hormone,” Breus says. Take selective serotonin reuptake inhibitors (SSRIs), like sertraline (Zoloft) and paroxetine (Paxil).
“All of these chemicals are big players in the pathways of maintaining or initiating sleep, or chemicals that help you feel awake during the day,” Winter says. These neurotransmitters play another role as well.
Chris Winter, M.D., of Charlottesville Neurology and Sleep Medicine and author of The Sleep Solution, tells SELF. “Generally speaking, these medications affect neurotransmitters like serotonin, dopamine, and norepinephrine,” which are important for regulating your emotions, board-certified sleep medicine doctor and neurologist W. Although different people can react to the same medication in different ways, there are some basic rules for how various antidepressants might influence your sleep.
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